Enhanced polo-like kinase 1 expression in myelodysplastic syndromes
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چکیده
منابع مشابه
Polo-like kinase-1 in DNA damage response
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA ...
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Activation of the NFκB signaling pathway allows the cell to respond to infection and stress and can affect many cellular processes. As a consequence, NFκB activity must be integrated with a wide variety of parallel signaling pathways. One mechanism through which NFκB can exert widespread effects is through controlling the expression of key regulatory kinases. Here we report that NFκB regulates ...
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BACKGROUND Human polo-like kinase 1 (PLK1) expression has been associated with inferior outcomes in colorectal cancer. Our aims were to analyse PLK1 in rectal cancer, and its association with clinicopathological variables, overall survival as well as tumour regression to neoadjuvant treatment. METHODS PLK1 expression was quantified with immunohistochemistry in the centre and periphery (invasi...
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Polo-like kinase 1 (Plk1) is one of the serine/threonine kinases involved in various mitotic processes, such as centrosome maturation and chromosome segregation. Although Plk1 is increased in several tumor types, the effect of Plk1 in gastric cancer is not clear because of the limited patient numbers in previous studies. This study was performed to investigate the prognostic significance and th...
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A structurally diverse dataset of 530 polo-like kinase-1 (PLK1) inhibitors is compiled from the ChEMBL database and studied by means of a conformation-independent quantitative structure-activity relationship (QSAR) approach. A large number (26,761) of molecular descriptors are explored with the main intention of capturing the most relevant structural characteristics affecting the bioactivity. T...
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ژورنال
عنوان ژورنال: BLOOD RESEARCH
سال: 2019
ISSN: 2287-979X,2288-0011
DOI: 10.5045/br.2019.54.2.102